	   SnapGene      GGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCGCCACCATGGGCcatcatcatcatcatcacGATCTCAATGGTGGTGGTGGTGGGTCGACCATGCAGATCTTCGTCAAGACGTTAACCGGTAAAACCATAACTCTAGAAGTTGAACCATCCGATACCATCGAAAACGTTAAGGCTAAAATTCAAGACAAGGAAGGCATTCCACCTGATCAACAAAGATTGATCTTTGCCGGTAGGCAGCTCGAGGACGGTAGAACGCTGTCTGATTACAACATTCAGAAGGAGTCCACCCTGCACCTGGTCCTCCGTCTCAGAGGTGGTTGAGAATTCTGCAGATATCCAGCACAGTGGCGGCCGCTCGAGTCTAGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGT  2�                                       !      (                                                                                                                    "            #          *            !            "            
                                          2                                                                        "                                    	                              "                                    !                                                                                 '               !                                                                              	               $   )            "                        #                                                      !                  +                                     "         ñ y‚ƒ„‰Ž�ž¿íö÷›œÅ	m
0mïzü­éû yzœ¸úNŸ¨Àl	L
Q
eÒðM{ýúÒ¢A¬y- – ò �¸…Šø!©ÛÈs	Ãn®SÁü · `æ�Õ�Êî�îŽ	Æ	"
a
n
1
¾�B¦ê� C “�ûO} åñ	w	ý|£. #1X©ß?·ÎM
™Å÷N-³û0¾þBÛbzŠ f{£Ám$	6	<	W	s
ÿ
i¬Þñþà¹�Óî­úÔ( z¹Y”-þ	R
!ÌØfÓ• �D÷¬¯²µŸ5r†‹Ç"'ÜÉt	ê	–Ä„*Óé‡cT $žåêsÜK]ù$Îãs�²È<]š — Lm¢*ªâ…c	Î	oº(m„ëc¯ä#Âý F ó þ¹�V
¹¹0¯Ú6ñ! œ açîÁÜÇ	#
b
±
Td|É ®�‘ÇàF‡¦Ð¿‹¡ë‚ o ®õR©'O�·¿æ.�	
o
¥KU)f( t 40\ËÓï‚žÚ"�èú|	„	Ÿ	¸	

W
£
´
Ç
2M¿ä¿ÚÁTC÷§ÜŸ ¸ +ìŽÄÖï}ºÀôk	
 »o(:ì³ D üW�ÓV¡Ú¸¾ãæò:	z	
g‚ÆS¤ P¦0	x	’
™}àÌ|
/ M ”ž~ÌmWþ‚Ü7,JÂf’ X y�Ð	ï
ó
(úa¨òÊeÂWÐ ˆ î$z2ªê2ÛG
N
e
%÷ø´üä –ÿCc´ 8YàÏ”
â
št¶ÎO	Š1…ÃÜî‹ë ‹ ¨ª¸ò	�Æjö~{“à  ôaä@N	ö	@.O¿Ä  ° GÂß7	T	¨	§
 ßR ½ gý²ûîÿŸá”�Ä®Õ Ï |=l¤°Öcnw•J	X	­3›¡ºzÔâã  €£Æ3Aè%	*	=	t
Â
jâòFŽ™¡ïûd¹Ëùû0)19 Q]†Ùâ“ÝÒZÿÿ	
;
"aT…Ôbu´% } É •­2	˜	Ù‘’;… Ö {rºCò.¡Š	S
µg«–—„_ y 8CR½+9ÇÝ	á	×
uÍy}œÐaÎŽ  ‘dø­°³¶ ¿‡ŒÈ%(ì+µÌu	
—¹Çk…çê¼… E7ÝásìÌQ]dU < > »ñs#¼¾Ê±	ÅÊ+G�ˆƒ R ö 6¶ë	5
h
Y¿IÔºØÏ$ O ëL^oéÞ-Í=^‘P å %mŸæÊÝ±ä3tŽ³.LN + `–½-úí5	˜
%‚’‹ÏÉ	$›…ä 	 ³ ²Ë#Vótù
h @ Æ ñ£ >
á»h2@9};mpÕý”� " ˜ Û Õ+†Ä)Ôì'Í?[Äå$Ã Ÿ Mn ¤cÛA	ËnÃ…I©dlb–M û d{«ã 5†d	³	Ï	&
EYp ½Ë&4XÞrS°âþ G Çºp™JVº1Œ“" ô T‰Ü3–ÍuŒÀN¼	Ø	A
|
º~ÛŠ Bt¤ …ÿh—ÎiWŽ}°7i0É €�DÓ[æ	rè„ò JkèÂÅÝ

J
¯
²
Êcíx‚ÅÌáÑaâ‰Ò V ® ¨c
à
ñ
e}ƒÈˆÄbÊÀŒìƒ � Ä bïa5$
ß¯0‰>G§ÿ¢K T ¤ 0JRÀ	È	
-
7UW;ë5v’³Áh€	f·" ¯ S	ÃP¯‘´2ãç+/µ`	Â	û	
/
p
8¦©¿tw‚*Á Z p à™ñ
9R	ª
5"Lp¿ìhÚYgq  „ ö(_d¸öú>BF	¸
ê
*Y=;R`ûbg€28·   ª‰ºÀ\	�	õ
KV-&# J ¦ 5Yeå¼ê’ž 	¹	
2
X
¤
µ
ÀôÛúÀ_°ÂC?DeZ¼ e 9]=Ò}	…	
[
È
Ñå¤ÖøFy  8 u ‘ © )1oÔaƒ¸éû	o	¾
†¤üÀªBœÙH¨ U*  1 {SÈÌðX‘ŸÛ#	£	7
‰
3N-Û7”¤µÕUx·Ã8@·ÕÝ�ªé—Ñ  HÅt»Ál	«	®	j
�
=Š¡¼*ª×ô;Öû>n ' ¹ rÆ…�8Fvð
9I‘[p)Ÿ¬#÷WsG¹ 0ñíø"~ÄÊõ‚BL­	ìjí€%! ,<J¦ÏíýÕ×LTö
`lu�‹–Ê	í	Ï
]ˆ>Z]´� • xMÔœõ¨ÚkÇÄ	P
/ûÑ¥x€Àú "X|W“¢ä5	;	ý	r
h×,”¸Œíùa E ýž4qb	¹ƒ/Ç" n s › í&N¶ÛÙå!-¹¿çóù{	
LS€ß'9S¥ÏT~¾e œÒ·/	y	'ù§~�ÁÛ6I Š í`y§ãé1Ú“
õ „•}Ãê ¼ Å<±S	šžy˜áú“âQ0
 QÑ¬þ1	—	Ü	‘Í Q º¾µë*àg
æ»P¹‚Î  * N ä l•±Ê"Unì4Ý—
#-KOg ! Ú ú ŸðÿÃ…Xÿg%Ý&8>|RZaÃ
“ 2„ÍÒMZI}ƒ/s j`4IQ¿	
I
ß
ð
Þ:b‚êËþÃ`aáJÑ Y ¹˜³âõ	*=Qô
)4:Qú!f¨¾svë,À7X¶ d XnzRé�‘Ñ		1
û£©¿^Ô¶>?E©è & ì<ó\«"öú m r !%{3›jO
R¸Þ&8‹Ðì ½ødw ‰ Ð;«â.	R	Û	&ø��5”—P ¹ÉƒïÑë3Üf
–
 |å"N	rÍ % c Wm�ô<	H
Þ
�3Pùµý=!rDàµ :áÐó;	•
·2OÿÝ
%7œ4Šë!ßÌv2 \ ¯ÂßQÍÎÏ‰Š‹�ž		›$56no23†‡ˆ‰Äéê	
ÜÝÞËÝï[\istuìí ] 'è°Ãâ9RZ–ŒŸœu.BKÏpjŒîö ¡gàßÐ:ã
vP‹NRÅ0ñÞð]ò (ZŒßé]™Äã©S�¹ó	¬
�v%gEÁk�á á Wu>N°'Ž/7Læî^§±|”«ï÷ ^ € ë :©[ «¯I¥CÐá,76  Œ ç ±—›	Ç³k÷qL @oµ	b¥sÀj¶ß j Ì7rADšO	”	ä
ëµO^ó ¢ÏhçÑ;f{÷	Aw"vñÆ1—Åñ, !ØáõàåKTŒQ/ŒPˆSòn 
)�êB^šä‹ªÑà›U	¡
z”ž&·�!'A † [àTŽ8	H	ˆ	ô	w´àhÞ*ÂÉÎ ± bÅº€ŒËÓŽâ  ÄûHÁºÃïø7@³©	¨
­
[€øFES‡l  â ÿ jvhK±ü(XÜ8½Qz_€¾ø XåOh#0Mý š•ï4¯}ð ¾ Â³	�ï&(¬Ú À ?þº
”îç âžÅ¨²•›Ö � Ì Ó NƒÖ�Ú>\f¥‚K	Y	^
ñÑ-�8vØ±Æ Ð Þ ì ÷ ø/<;m×¬J)d»{ã4® _ ˜}±dox–¡¦¯	œDTÕmä¹Üæ	 *uªx}[°�Õ€	Ó
®4¢bâ¥7w 65a˜ó>	œ	
ç
ì
²'?IÈlrzœ‚ú*" è ¶¿Z²’•˜›ž4é+	ž
,‘Ô”=|‰´ÑøiæMèºÕ½  - � '¤ÇB
QüD&	u

kó„ �¢ð\e¯ü1:2 �ùµüp	š
Ã
ã×ïoGšüv!+ÌJ: µ ï "œãw¶õ[½  
b"éõ« ªˆ& AA¡ 

#U—ðcM•Á›· R^‡Ú+”Ó
yç<
÷
Ëkà  Â pÍÞc.¦^	¼
†Õtv~µÓ� ¼–3	•	ó’¶Ù<|_  h k ~ Í8p®B›P	’	™	,@IßélPô Ê ´%Xså
Úì'Ç¼Ø @Eç“û† £&-óA<‹	ø	D
T
B¶];¨¢¯/?`-	 × H¢—wòý˜ |ª»iBÒ˜2ÆA  sÐDè;/Gg|û
hx#¬ÙÇ…jò —� z 9vÙ:Þ	Îz§–0ÝbWÇÙ�´ ?¬ˆ¾âö æUØ
Û
~¢TB¬óoG 	/‹Ââ	„
Ë
��Rä*öX D‹"S„á,ÈLvè�ÑQ‰Ï( Ž_›åùŒ·�ˆ�§¾Éìír	�	`
Â	l½�AR B ’e0,>¶ÍðV	v	 ˜«Ýü²½Ú Cr«®±´Ž¡&)á„•'l¸±è;\Ù5†™"bB" *3­ëôQ¨/[ÀÒœ

V
¢
{ŸºÈãÿ­E†¤ë²ž( L ¥UlÙ�Ïâ9	`�ß+Re{	VÏ ‡ óM	ñ	õ	F
öµÍiã’³ß  Î F2@kçÕÞúb”)	I	§	¦
Á
íáE ÃÊ/ x È Õ 7P\…Øáq’Ü*8 ‰	tSxªa³:ƒ^ ; = õ$´»½Ë4
¸ÆjÉËFH×\ ² ¼ò
	�‘,Ì�„ã ? c£4²	DÂÓÊk:oÔ� ÆgCht¿»	×	å	@
{
q�Uçh‰ÿAÈ S £ IÄ,
®
/4ˆ²ÄÀgeˆ ƒ Âˆ®^ðù8A´ 	[	ú	©
·
_aJo¾Ù1%  0 7 � ¨ (»·¢	6
Z
ˆ
…óùBÕG»xT–Ð!  ¥ÅüG÷!7EsÉª	ì	i
Ž
Î
\�‰�=ZÕ=rFœm ” š wìLMpô§ÙÆøR.Îù ì_Ñý¦ÿù’Hé   P Ù ã ù k1þ´ê)LYßf{Q`�  i_²PÝ9¢¾½>_ç¿ $ b li�ÏMO~ & çfÞÞP•ˆ1Nþ4› /ðÊñ à æ Y=M&®¤$²+fåK6]5° nË×æ™¤ez!u´ð– 	aÃúÐî6²‡	³Ê)œ&†@ ¿ Jg	"“™%' Ò Ý —Õ.;|Z�®Ô	]
ðŒ
l3­°ÅÛå , ¾4´ûP	
™
�Ó&HƒˆÖÐîny›å[ç ¼ ´ Á î !›Ì*ô@-¼»
!ïèô}ªšŸ© 
 g ³$Wo?+Øú{Æ× ,ú
>i@–œ >uÿÊ
ç•¡Üã)A«Æ³  A ¬P§q¦ƒïq	_
âþ¼¬Ž:Ø4˜Ù w Ç Í Ô O„×p‘Ûò?¤)ÔaL	À
R€âDŸ‘²Þ : ¢g3	Ö	?
ipÒj9nÖþÇ ‚ ¢ F]DrÿZ	+
‡
ˆò.3‡An~<dqw•› “ ™ ø 0¦³ØÅK¼æè # a ß <ekÖÝ%‡˜£­*eÎJ5\É Ñ Ü ù3f­±!‡Õímšäæ%¯»Ä í  š=+n,» *Û(|@ªÅ=ÿ? ¡ Oo¡¦E`qîþÕ	o†imž×c—Ý ` ™dÜ¥²º$e—¢¬°åÈ>ºç'   N¥_p§¨©ª«ëìíý	Ó	Ô	¦ÌUVWXJKefgh¥Ö W=¥¦ ~~½H]cp…y 	B	§�ÍEYÄDLªï¦nXCN§
 « Ê^|z!	C	�	Ô
F5qžÂ¾÷'5-oTîæ ü vä¯FZYós¢¦4D¨ «ûy~Ödq!\±�e	Ð	¨EOZ]°cð	ß§8YxãO! e¾+%Igl†¬6‡Ö´	'
£ÎÅãE˜žM«Ì±¡ÿ }™T{"	‚	�	ý
ÃKm·¿ø(.ïç+ 6»UÊðÅ9
Õ
í
³rŸšs# ÈË?	
nqÉW»½2{p�ƒ‘”û" H ¬ 7b_t}ôD	è
5G(6@J¢®6�U  wšêÁO½	-ÕÒù#Z¹N_é§5¾ é UŠ·Ý[—³§Î5�IÿG,	Ù	P}Ûz’ç»l¥ö© õ ý À4“–™œv}
Ÿ
’°özŠµ»Üt£CuÓÖ™Ì uFŸåB
‚
•>G[Ý%9¦×jÉô×‹E   . Ž i¬j×²ÇÍ'	¥	©^j�±8f°ZyP ( êÏüzÎò“XF±d ¨j1 ÈCe"1]Ñ	P[…–~àB£ñ;™äý2;Ÿ  †¥˜rRýE‘f	v
€
lôÅñ
!�]9ôÊ3 Ò‚ú”­i~ˆ“h	µ	ç	Ä
ÏØ™WÍépH"¬öK  €€ˆ¿,�¶7×	›
¤çsäFðN:…wß(, ‘&EJZm(
x
‹
äÆŸÇ›ýëó¢ 3 f=ýh‡¡ÔÝ%\q
	/¬¹ó‡²Í5; ¶ ð x· š	!
K
l
dÑîLyù¬¡@«è, ~Þ#	þ
ËÄöß/ý‰Ó' #�äKléöÛJ\ÆUÍ	é		#ƒ¸Íâê)rŒÒb®ãð Ã�¾|j	ƒ	ž	·	
°
³
Æ
c¾ÙnÀÆöJÛŠ  W xVË½
‘
î
ò
fV˜ñÉdÅËÁ‘ 7©d
á
$?Œs‰NÂí ¯ ¢ü¯v~2 cœ¸ø8 | BB¼ñÆà	
:
Ö
`´|„›t�Ï`–�„$ cð6°	
rëX¾ Ž„#	 _,Éèø
°Š2M ž Å bÔÚz@	%
=
àÊ1¼?H¨3WÌql•üáL SˆÛ•Ì–‹o˜|‹’£! U ­ Ã /§	
6Vìuw=É¶  ßc1E	_	Á	.
é
X7<�
gp$ I ¥ 8dÇä<W`n	½
£Ð,Ú6A“›£¯´wÂØ7dY¶ÔŽ) /;IqÎðÔ„KSu~õ	_kt€Š•Ã­	É	8H)AK‡©¬ÖYëiž$V¸ ’µØä ,4	a	Ã	ü	q
.KÖú+“¤·}`¿ » 
Äx›°è0¶Ù–	ô€ÀÚxƒáÂ  ) ° !T½Â„H$%º=O¸.Y" Q¸ë—è3Há)P¾	
0
;9é]Ó [§ªu`êõù¨+6I l q ¸È‚VÏ šŽ-	Q	Ú	Ý
Q€{<q“¼q÷ [ ®Áá9Ì9œò:	-AJuÜ#mMQèÛZhrõ   ê Vt‹Þ\˜¨¯ Hš	«
6~àDÀí¦ª i ?´Î6qCJS“	‹êr‡iµm+ … AŠÀ¹÷?šG	 
Zy“÷‹¶ÝÈÒ DÍ  þ iÁäW¹
Û¼íüPy3½šÙ Ë ö M‚÷�Ù)tewŽ	Ò
Sa(cu¤v×¸# µ&5Y‘”—š�ø	`òûCo~
�
æ
ë
+±>“<{hu®*�IÔ9 v xæ]	
ö
–L”ÊÒŒ‡ »‘	?HÞæè&òk»  ©%G:@AFC
\:§Ø¡®ü. Š«‡.ƒŠÁƒ
Ú
¦
VõWØ'F 2ó.Z�/€½ë=Œ	
U
ªÁkÜûD±@£°[±aQ  K 61jækØù“ŸÎ(	¦	ð	E
¥
õ_©`²9‚z. fôB	³º	ä	3
z
C·�ÁÈTÉæEg@[  / 6 � § ¤'‡­È¡	ù	Y
�
¶
Í
„�^<`±ÃÔf½0 Ø ^ëÐýóO÷e¡¥þøG L”dy£ ï Ô:I{ÏOY€Ó~	†	
\
ÒG²˜xZk2? f )>É
æ×óù©™z 9 v «p(CÓ2	p	*
†
¿
‡ýQ«áC3š ’ *2j †Úl™I©<þ }¼DG\bo„¤¹#^êüÒ	¥Cî�¤ÿVÇ<B¤ ª Éú$ÕfkDN\¯Á—�ö,ò¡íå3  |TÉïsÄS8
ü
4m¡­¶¼�!!  tE¦™HþF�
OõyÜ$8¥ÖÚy"‘¸È^ÖkÒõ˜Ë   éÍñ’0ÆÌ¤	iŸ•ÄA:˜óž 2 ‡Ñ“<Y Ü$h}’		g	w
Š
.æV¸Æò9†Þ'«êõ4 ÚI€	i	¶	Ì	è	k
Å
½ÐØõÞq‹IÚü?­Ÿ { wû®u¼ß	�
>_‹1{�Î_÷�7 •ÙŠ¯	ê—1VŠL+  .:HïÓƒÆã;V^js‰”Âm	¬	¢Ï+¨«Ù@š<X×êcXÈ#µo ( º ÿ·çG×à(ƒØ:JèG\*£$·àôø-XH >sÇ�­ÀUË8Ü
Štq;†C´p* Lh�@ŽØ‰�¿ã÷ñVn�™	œ
Ñ
x’Ox­)tÑH ¨‰$†-‚9? w
Ù
¥	åñ ­UÑº 5 1ò0†Œ.øã	ï	y
Œ
Ì
ƒŽÇ
S_°ÈÓå� ÓKNNcxöî÷Y> 
ù#'F[jn£)
…
CM®íõk+œþì£ ’îÃÅËåž »&ô -GîØâU‰]r	Ë	^é0?ŽU^Š‰ž6  =Kg§þ�×#T>ÿÊÖß'm‚Œ˜Ð
w‰¶Ð³Ð) 4 Ò…-Mi¢÷Mbwî	^¯ºÒô=" EFÐÑŒÖþˆÉÕÞ&av—[\]­®RSTˆµÎÏ<  +\  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                             #                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                	                                                                                                                                                                                                                                       !                                           	                                                                                                                     
   	                              
   	               (      
         	                              	                        	            	                                    +                               h   I                     I                                                                                                                                                                        #                                                                                                                                                                                                                                                                                                              	                                                                                     !               	                                         
 	          
 	     (  
   	          	        	    	            +           h I       I   fˆ  g`  g~  g¢  k\  o  tTÝ	uæ†M”¯	Ïèq1×î„ç/) ª;
$ªÜ�a,¦íû¾a7	7	|ñ9� ,¦ÆíJb¼Ô=Xvñ9l»Á¹	
$
¯
µ
*N}ˆ	5‰Ì>wû·\¨t
„Îymt
’
„t
„t
yt
%	Ay� ‡×*¿
‚ŒÂŒ*	)ŸB5cÛSÈ!‘ ”%÷Ë‹Ô%	}"	'	ö–Æï0Ïf!óQ†Ù“º’™",
eË
�`	sg©s5¿Ç	ê	UÆV+ÙaÊÐ	jßÃj	
Ÿºn] ¨ŸBE
õ3Q†Ù“Ç	…Ô¡jÂ Ù× y5
ó
IÏ$DI$DTÉ	ÕÞ ;¬)d4öq]ÕŽ	ë	I$D
yÕÊî�1–¼!Ç	ª¸ö>Yú˜
àÔ2ç)	‹	þ‚¶I­	ù	×zIQÇ	‘Å0©sÕ5žª¿Ú"Ç	ê	-TU³Ü¯ýûæÞOy‘õøPÌ*æö
@‰-Ö™¼ö	k
x
¯(`Ùç	Ýp¬ª
¿uÙH¼×ÙUãÃj	ß'¼êÀ?‡Ãj	¸`ø�–@‰™x¬ yÕÊî�Ž	ë	5
ó
1IÏ$DÜÌ’@‰™öx•ž%÷V ,íY]´¸FTãö+>\	
ñ
39UY‚†¼×>[ÈCp÷@‰™xÕ¸ö>Y*Å$	s
iñ�˜îúú0® }5`òæ
>%\:.	dÜÈÜÉÒ‚i~ˆ“Wé"y²E
õûæÞ3á)§u¨ø@ÁÆ ºÕ™"mÆ ŸñºÕ€ã+’™I.$"D¬ ŸÎêÏ×,	Ù	q©Õ/P•Kø~àB’ÜßÌ+5 Â Í…@ ¼×ãè0
]cX»�
TÉ­ù	è0
]º™"jTÉOy‘õ«y Ý	yŽ'T·ïŽr	ÂR ±"Ug[)„ã'"êÏ$	<	s
iñ�îú(€Â
âF™ûË91òŒ.×J
*£°…—ÉP0	Ì¦ P2 	
/
X
µ
8_°Âe¦©t¼*· +ì��ÕÖîÌ³ñ		Ë	k
ÐŠ?žDÜcT‚
ô×E�ÌñP2
/
8¦©t*¦  	X
µ
_°Âe¼�÷ñnœ
’­)HßT	 ½bõ®	 ¦ PÂÅ2Ál	 	«	


/
X
¯
²
µ
¡*8ª_°ÂÅ;Öe¦©t¼*‰n1òŒ.×		Ë	k
JÐ
*£°Š?ž_úBê
*=;g€8 GÂ¨	§
R-<‹	T
¢¯`( ÿƒG$·-XÁ6	ÿ
Þøou*I ™"¸^K kØÎ_zy¸Q
eÒÓ["œãõ[¼óA B¶"–é0<? K ’ ™kØÎ_"¸^z½ºO¸%@C
\:§¡®.Ý…Ôu´¢-GîâU]r?J
cíx‹ rC~Ì.­3g¡Æj«ö‚„
:
`o„˜t‹’!$ }úiwšj×­Í"	'	¥	ý
^ÃÍ.±8öyù#jCM®õ+ì$z2N
ÿcmÊ+7A
s)t³'?ŠÄ]ˆ ª%÷–Èe[–ñä2Ÿ~Ì‚rC.g«„7A
sŠ]‹ ­3¡Æjö ÂÅÁl	«	

¯
²
¡*ªÅ;Ö‰n%½@C
\:§¡®ºO¸.† ô	´hü ¯s¢ˆ&”KU ­ Ã /§	
6Vìuw=É¶ .:HïÓƒÆã;V^js‰”Âm	¬	¢Ï+¨«Ù@š<X×êcXÈ#µoJkèÂÅÝ

J
¯
²
Êcíx‚ÅÌáÑaâ‰Ò	 ³ ²Ë#Vótù
hd XnzRé�‘Ñ		1
û£©¿^Ô¶>?E©èT ¤ 0JRÀ	È	
-
7UW;ë5v’³Áh€	f·Ø ^ëÐýóO÷e¡¥þøG€£Æ3Aè%	*	=	t
Â
jâòFŽ™¡ïûd¹Ëùû0)19¸ +ìŽÄÖï}ºÀôk	
 »o(:ì³ÚI€	i	¶	Ì	è	k
Å
½ÐØõÞq‹IÚü?­Ÿ… AŠÀ¹÷?šG	 
Zy“÷‹¶ÝÈÒ DÍ& d t ¸ +4ì0X\nzŽRÄÖìËÓéï‚�žï}‘Ú"�ºÀÑèôú		k	|	„	Ÿ	¸	


1
W
£
´
Ç
2<M »¿äû¿Ú£©¿ó^oÁÔ(:T¶>C\«ì÷"?§³ÜöúEŸ©è … ¿ þ 	aiÁÃúAJŠÀä¹Ðgî÷6?Wš²	G	‡	 
¹
Zy“Û³÷"‹“¶¼íüP™ÊÝ%')yœÈÒ &3D†½šÍÙ@R^‡Ú+”Ó
yç<
÷
Ëkà ƒ Âˆ®^ðù8A´ 	[	ú	©
·
_aJo¾Ù1%E^ € ë :©[ «¯I¥CÐá,76’îÃÅËåž »&ôD üW�ÓV¡Ú¸¾ãæò:	z	
g‚ÆS¤# a ß <ekÖÝ%‡˜£­*eÎJ5\ÉE d R^‡Ú	+”ýXnzÓ
/R‹ž4qéy�Âç‘Ñ		b	â	1
<
„
Ë
÷
û�¹�£©¿R^Ôƒ¶ä/>Ç*?ËöXEk©èà 6»UÊðÅ9
Õ
í
³rŸšs#   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  %C<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="0" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="902-911" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3539-3555" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3515-3531" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="6xHis" directionality="1" translationMW="840.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1192" maxFusedRunOn="1192" detectionMode="exactProteinMatch"><Segment range="914-931" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;6xHis affinity tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="HHHHHH"/></Q></Feature><Feature recentID="4" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3608-3629" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="3563-3569" color="#ffffff" type="standard"/><Segment range="3570-3587" color="#ffffff" type="standard"/><Segment name="-35" range="3588-3593" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5534-5638" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3345-3466" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2161-2296" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1269-1493" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="ubiquitin-K48R" directionality="1" translationMW="8593.06" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1192" maxFusedRunOn="1192" detectionMode="exactProteinMatch"><Segment range="962-1189" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human ubiquitin variant in which Lys-48 has been mutated to arginine&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGRQLEDGRTLSDYNIQKESTLHLVLRLRGG"/></Q></Feature><Feature recentID="13" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1981-2310" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1539-1967" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3917-4502" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2377-3171" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="18" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5464" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4673-5464" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5465-5533" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¨<Notes>
<UUID>70de651a-dbdc-4dea-b27e-387d8659578b</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCDNA3.1-6Ã—His-Ubiquitin-K48R</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="3:28:29">2019.1.7</Created>
<LastModified UTC="8:35:22">2025.7.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                              ³<StrandColors><TopStrand><ColorRange range="1103..1104" colors="magenta"/></TopStrand><BottomStrand><ColorRange range="1103..1104" colors="magenta"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
